Thursday October 4thFriday October 5th Saturday October 6th

Thursday October 4th

08:00 -09.00

Registration

 

09:00 -10:30

Symposium 1 – CME Program                                                                                                Room MR 10+11

New horizons for oral anticoagulation in coronary artery disease

Chairs: Sigrun Halvorsen (Norway) & Freek W.A. Verheugt (The Netherlands)

Upstream versus downstream thrombin inhibition

Christopher Bode (Germany)

Oral anticoagulants in ACS patients

Robert F. Storey (United Kingdom)

Direct oral anticoagulation in stable CAD

Freek W.A. Verheugt (The Netherlands)

New targets in coagulation factors for arterial thrombosis

Hugo Ten Cate (The Netherlands)

 

Symposium 1 – Translational Research Program                                                             Room MR 13+14

Joint symposium with WG atherosclerosis and Vascular Biology: From atherosclerosis to thrombosis

Chairs: Johann Wojta (Austria) & Klaus Preissner (Germany)

HDL in CAD: a key role beyond atherosclerosis protection

Gemma Vilahur (Spain)

Smooth muscle cell plasticity in vascular remodeling

Marie-Luce Bochaton-Piallat (Switzerland)

Cardiovascular benefits by neutralizing interleukins

Sheila Francis (United Kingdom)

Proteomics and metabolomics in biomarker discovery for cardiovascular diseases: progress and potential

José Tuñón (Spain)

 

10:30 -10.50

Coffee break and poster session

 

10.50-12:20

Symposium 2 – CME Program                                                                                               Room MR 10+11

Therapeutic strategies in ACS

Chairs: Bianca Rocca (Italy) & Sigrun Halvoresen (Norway)

Do we still need aspirin?

Robert F. Storey (United Kingdom)

Duration of dual antiplatelet treatment after coronary stenting/ACS

Ángel Cequier (Spain)

Old and new indications for intravenous antiplatelet drugs

Joao Morais (Portugal)

Biodegradable devices and thrombosis

Manel Sabaté (Spain)

 

Symposium 2 – Translational Research Program                                                           Room MR 13+14

Coagulation and Fibrinolysis

Chairs: Agneta Siegbahn (Sweden) & Walter Speidl (Austria)

Tissue factor in coagulation: the length matters?

Henry Versteeg (Netherlands)

Regulation of TF on monocyte subsets

Stefan Stojkovic (Austria)

Tissue factor signaling: beyond coagulation in the cardiovascular system

Lina Badimon (Spain)

Importance of fibrin and its lysis in ACS

Diana Gorog (United Kingdom)

 

12:30-13:30

Sponsored Lunch Session

 

13:30-15:00

Symposium 3 – CME Program                                                                                            Room MR 10+11

Selection and management of optimal antithrombotic therapy after implantation of a cardiovascular device

Chairs:  Diana Gorog (United Kingdom) & Mathieu Kerneis (France) 

Transcatheter Aortic Valve Replacement

Dirk Sibbing (Germany)

Left atrial appendage occlusion

Giuseppe Patti (Italy)

PFO and associated disease

Mathieu Kerneis (France)

LVAD and heart transplant

Marisa Crespo (Spain)

 

Symposium 3 – Translational Research Program                                                         Room MR 13+14

Obesity and thrombosis

Chairs:  Dirk Duncker (The Netherlands) & Harald Arnesen (Norway)

Macrophage polarization in adipose tissue: the key step for inflammatory modulation

Johann Wojta (Austria)

Adipose tissue, platelet activation, coagulation and impaired fibrinolysis

Agneta Siegbahn (Sweden)

Impact of adipose tissue on insulin resistance and diabetes

Ingebjørg Seljeflot (Norway)

Epicardial adipose tissue: a predictor of cardiovascular outcome?

Charalambos Antoniades (United Kingdom)

 

15:00-15:30

Coffee break and Poster Session

 

15:30-17:00

Symposium 4 – CME Program                                                                                          Room MR 10+11

Joint Session WG Thrombosis and WG Aorta and Peripheral Vascular Diseases: Antithrombotics for peripheral arteries

Chairpersons: Lucia Mazzolai (Switzerland) & Robert F. Storey (United Kingdom)

Similarities and disparities of thrombosis in coronary and peripheral arteries

Marcus Flather (United Kingdom)

Antithrombotic treatment for asymptomatic carotid stenosis?

Lucia Mazzolai (Switzerland)

Antithrombotic therapy in lower extremity arterial disease

Victor Aboyans  (France)

Antithrombotic therapy after revascularization

Christine Espinola-Klein (Germany)

 

Symposium 4 – Translational Research Program                                                    Room MR 13+14

Atherothrombosis in diabetes: mechanisms and clinical implications

Chairs: Ingebjørg Seljeflot (Norway) & Charalambos Antoniades (United Kingdom)

Endothelial dysfunction, insulin resistance and thrombotic risk

Isabelle Johansson (Sweden)

Diabetes and primary prevention: myths and facts

Marion Mafham (United Kingdom)

Coagulation proteins and the fibrinolytic system in diabetes

Ramzi Ajjan (United Kingdom)

Diabetes and reperfusion

Charalambos Vlachopoulos (Greece)

 

Opening Plenary Lecture                                                                                                     Room MR 10+11

Chairs: Bianca Rocca (Rome, Italy) & Joao Morais (Portugal)

17:00 – 17:45 On Doctors and their Operas: A critical and lyrical analysis

Joan Soriano (Spain)

17:45 – 18:30 Coronary atherothrombosis: from lipids to inflammation

Lina Badimon (Spain)

 

18:30 – 20:00h

Welcome cocktail with visits to exhibition poster

 

Friday October 5th

 09:00 -10.30

Symposium 5 – CME Program                                                                                              Room MR 10+11

Thrombosis treatment and prevention in ‘special’ patient populations

Chairs: Erik L Grove (Denmark) & Joao Morais (Portugal)

Management of antithrombotic therapy after bleeding

Sigrun Halvorsen (Norway)

Antithrombotic therapy and obesity

Bianca Rocca (Italy)

Antithrombotic therapy in the elderly

Felicita Andreotti (Italy)

Antithrombotic therapy in patients with renal disease

Xavier García – Moll (Spain)

 

Symposium 5 – Translational Research Program                                                        Room MR 13+14

Inflammation and thrombosis

Chairs: Gemma Vilahur (Spain) & Johann Wojta (Austria) 

Inflammation and atherothrombosis. A tale of hope.

Jesús Egido (Spain)

Monocyte subsets and functions: predictors for cardiovascular outcome

Walter Speidl (Austria)

The emerging role of neutrophil extracellular DNA traps in atherothrombosis

Klaus Preissner (Germany)

CANTOS Trial – will it change our practice? 

Tomas Weiss (Austria)

 

10:30 -10.50

Coffee break and Poster Session 2

 

10:50 -12.20

Symposium 6 – CME Program                                                                                            Room MR 10+11

Joint Session with the Italian Study Group on Atherosclerosis Thrombosis and Vascular Biology

Challenges and opportunities in Atrial Fibrillation

Chairs: Jolanta Siller-Matula (Austria) & Guisseppe Patti (Italy) 

Strategies for prediction and early detection of AF

Francisco Marín (Spain)

Management of antithrombotic therapy in patients with AF and ACS

Andrea Rubboli (Italy)

Management of antithrombotic therapy in AF patients with valvular heart disease

Lluis Mont (Spain)

Benefits and risks of switching from VKA to NOACs: what is the evidence?

Erik Grove (Denmark)

 

Symposium 6 – Translational Research Program                                                      Room MR 13+14

Genetics and Epigenetics in Cardiovascular Disease

Chairs: Xavier García – Moll (Spain) & Felicita Andreotti (Italy)

Genetics in Cardiovascular Disease

Anne Tybjerg-Hansen (Denmark)

Lifestyle changes and telomeres shortening in cardiovascular disease states

Harald Arnesen (Norway)

Epigenetics in diabetes and aging

Tomasz J. Guzik (United Kingdom)

miRNAs and other non-coding RNAs as biomarkers of platelet reactivity

Manuel Mayr (United Kingdom)

 

12:30-13:30

Sponsored Lunch Session

 

13:30-15:00

Symposium 7 – CME Program                                                                                                Room MR 10+11

Unmet clinical needs in ACS

Chairs: Eduardo Oliveira (Portugal) & Manuel Sabaté (Spain)

Can biomarkers predict future ACS?

Bruna Gigante (Sweden)

Biomarkers as predictive tools for bleeding or thrombotic complications post ACS

Daniel Lindholm (Sweden)

Clinical relevance of P2Y12 inhibitors and morphine drug-drug interaction

Jolanta Siller-Matula (Austria)

Coronary microvascular dysfunction

Javier Escaned (Spain)

 

Symposium 7 – Translational Research Program                                                          Room MR 13+14

Joint Session WG eCardiology: In silico modelling and e-learining: tools for the future of cardiology?

Chairs: Enrico Caiani (Italy) & Diana Gorog (United Kingdom)

In silico modelling of antiplatelet drug response: a tool for personalizing therapy and designing clinical trials?

Gianna Toffolo (Italy)

The role of digital health in increasing patients’ education

Enrico Caiani (Italy)

Computer modeling in heart disease and thrombosis.

Alfonso Bueno – Orovio (United Kingdom)

Self-management platforms for anticoagulation: the PORTALS study

Marise Kasteleyn (The Netherlands)

 

15:00-15:30

Coffee break and Poster Session  

 

15:30-17:00

Symposium 8 – CME Program                                                                                                        Room MR 10+11

The long-term course of venous thromboembolism

Chairs: Hugo Ten Cate (The Netherlands) & Bruna Gigante (Sweden)

Risk factor of short- and long- term unfavorable outcomes in patients with PE

David Jimenez (Spain)

Risk Factors and management of the post-thrombotic syndrome

Arina Ten Cate (The Netherlands)

Pathophysiology and management of the chronic post-thrombotic pulmonary hypertension

Rui Baptista (Portugal)

The optimal long-term strategy in patients with unprovoked VTE

Paolo Prandoni (Italy)

 

Symposium 8 – CME Program & Translational                                                                       Room MR 13+14

Looking beyond coronary damage in ACS: the role of microcirculation

Chair: Lina Badimon (Spain) & Lars Wallentin (Sweden)

Coronary Microvascular Dysfunction

Dirk Duncker (The Netherlands)

Targeting microvascular obstruction in primary PCI: when and how

Borja Ibañez (Spain)

No-Reflow Following Percutaneous Coronary Intervention: Impact on prognosis

Eduardo Oliveira (Portugal)

Myocardial infarction with non-obstructive coronary arteries (MINOCA)

Juan Carlos Kaski  (United Kingdom)

 

17:00 – 17.45

Closing ‘Steen Husted’ Plenary Lecture in Cardiovascular Pharmacology                 Room MR 10+11

Chairs: Dirk Sibbing (Germany) & Gemma Vilahur (Spain)      

Lars Wallentin: Can we predict bleeding and thrombosis after ACS?

 

Saturday October 6th

9:00 -10:30

Symposium 9 – CME Program/ Translational Program                                                 Room MR 10+11 

Personalized antiplatelet strategies: one size does not fit all

Chairs: Dániel Aradi (Hungary) & Bianca Rocca (Italy)

Platelet proteomic signatures: towards individualized antiplatelet drug therapy

Elena Tremoli (Italy)

Can platelet reactivity predict ischemic and bleeding outcomes?

Jean Philippe Collet (France)

Inflammation and patient’s risk stratification

Tobias Geisler (Germany)

Is there room for personalized antiplatelet treatment in 2018? From guidelines to patients.

Dániel Aradi (Hungary)

 

9:00-10:30

Best Oral Presentations                                                                                                              Room MR 13+14

Chairs: Johann Wojta (Austria) & Mark Thomas (United Kingdom)

6 presentations (10 min + 5 discussion each) selected from the best
submitted abstracts

 

O 01 Development and validation of a novel in-hospital bleeding risk
score in acute myocardial infarction – the SWEDEHEART score.
Ms. Moa Simonsson1,2, Mr Henric Winell3, Mr Henrik Olsson3, Ms Karolina
Szummer4, Mr Joakim Alfredsson5, Ms Marlous Hall6, Ms Tatendashe
B. Dondo6, Mr Chris P. Gale6, Mr Tomas Jernberg1
1Department of Clinical Sciences, Karolinska Institutet Danderyd , Stockholm,
Sweden, 2Department of Cardiology, Karolinska University Hospital,
Stockholm, Sweden, 3Department of Medical Epidemiology and Biostatistics,
Karolinska Institutet, Stockholm, Sweden, 4Department of Medicine, Karolinska
Institutet, Huddinge, , Stockholm, Sweden , 5Department of Cardiology,
Department of Medical and Health Sciences, Linköping University ,
Linköping, Sweden, 6Leeds Institute of Cardiovascular and Metabolic Medicine,
University of Leeds, , Leeds, UK

O 02 Profilin 1: from inflammation to thrombosis
Dr. Esther Peña1, Dr Teresa Padro1, Dr Gemma Vilahur1, Dr Lina Badimon1
1 Cardiovascular ICCC- Program, Research Institute Hospital de la Santa
Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain

O 03 Platelet, granulocyte and neutrophil derived microvesicles map coronary
calcification and atherosclerotic plaque in asymptomatic patients
with familial hypercholesterolemia
Dr. Gemma Chiva-Blanch1, Dr. Teresa Padró1,2, Dr. Javier Crespo1,
Dr. Leopoldo Perez de Isla3,4, Dr. Pedro Mata4, Prof. Lina Badimon1,2
1Cardiovascular Program ICCC-IR Hospital Sant Pau, Barcelona,
Spain, 2CiberCV, Institute Carlos III, Madrid, Spain, 3Cardiology Department,
Hospital Clínico San Carlos, Madrid, Spain, 4Fundación Hipercolesterolemia
Familiar, Madrid, Spain
O 04 Glucose associated NETosis in patients with ST-elevation myocardial
infarction
Dr. Ragnhild Helseth1,2, Dr. Eva Cecilie Knudsen3, Dr. Jan Eritsland3, Dr.
Trine Baur Opstad1,2, Professor emeritus Harald Arnesen1,2, Dr. Geir
Øystein Andersen3, Professor Ingebjørg Seljeflot1,2,3
1Center For Clinical Heart Research, Oslo, Norway, 2University of Oslo, Oslo,
Norway, 3Department of Cardiology, Oslo University Hospital Ullevål, Norway
O 05 Use of non-vitamin K antagonist oral anticoagulants 2008-2016:A
Danish nationwide cohort study
Ms. Simone Bonde Haastrup1, Maja Hellfritzsch2, Lotte Rasmussen2, Anton
Pottegård2, Erik Lerkevang Grove1,3
1Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus,
Denmark, 2Clinical Pharmacology and Pharmacy, Department of Public
Health, University of Southern Denmark , Odense, Denmark, 3Department of
Cardiology, Aarhus University Hospital, Aarhus, Denmark
O 06 Uniform Prasugrel Treatment vs. Clopidogrel Treatment for Confirmed
Responders in Acute Coronary Syndrome Patients: Results from the
Randomized TROPICAL-ACS Trial
Dr. Ralph Hein-Rothweiler1, Prof. Dirk Sibbing1, Dr. Lisa Gross1, Prof. Dietmar
Trenk2, Prof. Tommaso Gori3, Prof. Tobias Geisler4, Prof. Kurt Huber5,
Prof. Stephan Felix6, Prof. Hüseyin Ince7, Prof. Harald Mudra8, Dr. Zenon
Huczek9, Dr. Daniel Aradi10, Prof. Jörg Hausleiter1, Prof. Steffen Massberg1,
Dr. Martin Hadamitzky11
1Ludwig-Maximilians University, Department of Cardiology, Munich, Germany,
2University Heart Center Freiburg – Bad Krozingen, Bad Krozingen,
Germany, 3Zentrum für Kardiologie, University Hospital Mainz, Mainz, Germany,
4Department of Cardiology, University Hospital Tübingen, Tübingen,
Germany, 53rd Medicine Department, Cardiology and Intensive Care Medicine,
Wilhelminen Hospital, Vienna, Austria, 6Department of Internal Medicine
B, University Medicine Greifswald, Greifswald, Germany, 7Department
of Cardiology, Vivantes Klinikum im Friedrichshain und Am Urban, Berlin,
Germany, 8Department of Cardiology, Pneumology and Internal Intensive
Care Medicine, Klinikum Neuperlach, Munich, Germany, 91st Department of
Cardiology, Medical University of Warsaw, Warsaw, Poland, 10Heart Center
Balatonfüred and Semmelweis University Budapest, Budapest, Hungary,
11Department of Radiology and Nuclear Medicine, German Heart Center
Munich, Munich, Germany

10:30 -11.00

Coffee break and Poster Session

 

11:00 -12.30

Young Investigators Award Session (ESC – WG on Thrombosis)                            Room MR 10+11                    

Chairs: Bianca Rocca (Italy) & Robert F. Storey (United Kingdom)
Jury: Diana Gorog (United Kingdom), Bruna Gigante (Sweden) & Tobias Geisler (Germany)

6 presentations (10 min + 5 discussion each) selected from the best submitted abstracts from the YTRG or anyway submitters younger than 35 yrs 

O 07 MicroRNA-21 Affects Platelets and their Releasate: A Novel
Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition
Dr. Temo Barwari1, Dr. Seda Eminaga1, Dr. Ruifang Lu1, Dr. Paul Armstrong2,
Dr. Melissa Chan2, Dr. Ursula Mayr1, Dr. Mahnaz Sahraei3, Ms. Marta
Fernández-Fuertes3, Dr. Javier Barallobre-Barreiro1, Mr. Marc Lynch1,
Dr. Xiaoke Yin1, Dr. Christian Schulte1, Ms. Ferheen Baig1, Dr. Raimund
Pechlaner4, Dr. Sarah Langley5, Dr. Anna Zampetaki1, Dr. Peter Santer6,
Mr. Martin Weger6, Dr. Roberto Plasenzotti7, Dr. Markus Schosserer8, Prof.
Johannes Grillari8, Prof. Ajay Shah1, Prof. Timothy Warner2, Prof. Carlos
Fernández-Hernando3, Prof. Yajaira Suárez3, Prof. Manuel Mayr1
1King’s British Heart Foundation Centre, London, United Kingdom, 2Queen
Mary University of London, London, United Kingdom, 3Yale School of Medicine,
New Haven, USA, 4Medical University Innsbruck, Innsbruck, Austria, 5Duke-
NUS Medical School, Singapore, Singapore, 6Bruneck Hospital, Bruneck,
Italy, 7Medical University of Vienna, Vienna, Austria, 8University of Natural
Resources and Life Sciences, Vienna, Austria
O 08 Impaired fibrin clot lysis persists at 1 month post acute coronary
syndrome: a PLATO substudy
Dr. Wael Sumaya1, Professor Lars Wallentin, Professor Stefan James,
Professor Agneta Siegbahn, Dr Katja Gabrysch, Maria Bertilsson, Anders
Himmelmann, Ramzi Ajjan, Robert Storey
1University Of Sheffield, , United Kingdom
O 09 Neutrophil extracellular traps in relation to mortality and coagulability
in ST-elevation myocardial infarction
MD Miriam Langseth1,2, MD PhD Ragnhild Helseth1,2, MD Vibeke Ritschel1,2,
MN Charlotte Holst Hansen1,3, MD PhD Geir Øystein Andersen1,3, MD
PhD Jan Eritsland1,3, MD Professor PhD Sigrun Halvorsen1,3, MD PhD Svein
Solheim1,3, Professor emeritus MD PhD Harald Arnesen1,2, Professor PhD
Ingebjørg Seljeflot1,2, MSc PhD Trine Baur Opstad1,2
1Center For Clinical Heart Research, Oslo University Hospital, Oslo,
Norway, 2Faculty of Medicine, University of Oslo, Oslo, Norway, 3Department
of Cardiology, Oslo University Hospital, Oslo, Norway

O 10 Selective inflammatory activation of megakaryocytes and platelets
by transgenic expression of IKK2 results in a hypo-reactive platelet
phenotype.
Mr. Manuel Salzmann1, Dr. Marion Mussbacher1, Dr. Waltraud C
Schrottmaier1, Dr. Julia B Kral-Pointner1, Dr. Ulrike Resch1, Dr. Bastian
Hoesel1, Mrs. Sonja Bleichert1, Mr. Bernhard Moser1, Dr. Katy Schmidt1,
Mr. José Basílio1, Dr. Alice Assinger1, Dr. Johannes A Schmid1
1Medical University Of Vienna, Vienna, Austria
O 11 Toll-Like Receptor Expression and Mortality in Critically Ill Patients
Dr. Konstantin Krychtiuk1, Dr. Dominik Draxler, Prof. Alexander Niessner,
Prof. Johann Wojta, Prof. Gottfried Heinz, Prof. Walter Speidl
1Medical University Of Vienna, Vienna, Austria
O 12 Reasons for early discontinuation or switching of antiplatelet therapy
in elderly patients after acute coronary syndrome
Ms. Marieke Gimbel1, Dr. Jur ten Berg1
1St. Antonius Hospital, Nieuwegein, Netherlands

12:30-13:00

Awards and closure of conference